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Inicio arrow newsitems arrow Virus: Biggest Ever Trial on HCQ+AZ+Zinc Cure (3.700 Patients) Found World-Record Survival: 99,5 % !

Virus: Biggest Ever Trial on HCQ+AZ+Zinc Cure (3.700 Patients) Found World-Record Survival: 99,5 % !

Escrito por ACM
25.05.20

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*Strasbourg/Angelo Marcopolo/- In the Biggest Trial Study of HCQ+AZ+ against the Virus, just Concluded this Month, among about 3.700 Patients (i.e. the Larger Ever in the World in that area, until now), the Mortality Rate was Only ...0,5%, giving a Global Record-Breaking Survival Rate of 99,5%, as Announced Today French Professor Dr. Didier Raoult, an Experienced and Famous Infectiologist/MicroBiologist Expert, CEO of Mediterranean and Infection Hospitalo-Universitarian Institute (IHU) at Marseille City, who had been already EnTrusted by Historic French President Jacques Chirac (a Gaullist) to daft a 1st Report for the Strategy of the Country's Protection from any foreseable Risk of Epidemic, already, as Early as since the Beginning of 2000ies, (just After the SARS-1 Virus of 2003+).

- Moreover, among those circa 3.700 Patients "retrospectively", treated with HCQ+AZ+ Nowadays, "we NEVER Observed Any CARDIAC Death and Toxicity", it was added by the Two main Leaders of that New Trial, (D. Raoult and Matthieu Million), where "7.800 ECG were made" on all those Patients, by measure of Precaution.

+ Already, with  "ZERO (0) Deaths" of People Infected by the COVID-19 Virus "before 70 Years of Age", and just 8 Deaths among Only those Aged "74 to to 95 Years", in a CHQ+ Trial with More than 1.060 Patients, Concluded Previously, at the End of March, and Published at a Scientific Review on May 5, 2020, the Results appeared very Positive, (See Also Infra).

Such Landmark Results also have a Key Importance for Crucial and Topical Issues of International Health Strategy at Global Level, Nowadays :

 - Indeed, the International Health Organisation (WHO), at Nearby Geneva, had Chosen, Among about 50 Various Candidates, ("Based on Evidence from Laboratory, Animal, and [Human] Clinical Studies"), the HCQ+ as 1 Among the 3 Best "Most Promising" Candidate Drugs in the World Deserving to be Tested by its Research Program for Medical Treatment against the CoronoVirus, ("Solidarity"), with 108 Millions $ Funding and about 3.500 Patients from 17 Countries.

Competitors are Only "Remdesivir" (a Failed attempt Initially v. Ebola in Congo, where it did Not work, while Other Drugs did, But Later reportedly used in Animals v. SARS-1, Needing an IntraVenous, and Expensive, Based on Genetic Manipulations expected to Block Virus' Replication, and Backed by "Gilead" Big Pharma Corporation, holding its Patent) ; and "Lopinavir"'s Combinations, (Initialy destinated to "HIV", with "Ambiguous" Results v. SARS-1 or MERS, and "Not Encouraging" First Trials v. COVID-19, it may cause "Significant" Liver Damage, But is now Tested v. MERs in Saudi Arabia).

=> So that HCQ+ appeared, until now, to be, comparatively, the Best Hope for the World Health Organisation. A Succesful Drug already against Malaria and Arthritis, Used withOut Problem Since the 2nd World War, now a "Generic", Cheap and Simple Pill, it Might Protect Cells from Virus' Attacks, Strengthening the Natural Human Immune System, But it must Avoid Side Effects, with right Precautions. About 20 Chinese Studies reportedly were Succesful against this Virus, But a Lack of Full Published "Data" was reported, with the Exception of French Professor Raoult's Tests, that Some considered Initially "InSuficient", until his Recent Work, (which, therefore, has a Crucial Importance Nowadays).

>>> Even More Important, World-wide :  It's a Fact that the WHO has, Until Now, practicaly Excluded Vaccines from its above-mentioned International Research projects, Focused Only on Treatments and Cure, (Comp. Supra), mainly Because of a "Need for Speed", in order to "Reduce the Time" usually taken by Vaccines' testing, (may be 1 or 1,5 Year+), given the Urgency in this Deadly Virus' Crisis. In Consequence, (and given also the Facts cited Supra), at least Until Now, Serious HCQ+ Trials appeared to be, in Practice, probably the Only attainable Hope to Find a way to Urgently Save currently Threatened Human Lives throughout the Planet !

--------------------------------

In this Context, Previously, Trials with HCQ+AZ+ by Prof. Raoult, concluded at the End of March, had Resulted Already High enough, with a 99,1 % Survival rate. But the New Overall Results, which just Concluded on this May, (Including Almost Four Times More Patients : See Infra),  Reached an Even Higher Survival rate : 99,5 % (i.e., by Far, the Best in the World) !

--------------------------------

Professor Raoult's team had Initialy Tested 36 Patients, Afterwards 80, and Later 1.061, whlle Recent Rumours evoked anew a Doubling of the Number of Patients for a New, Bigger Trial,  (i.e. about 2.000). But, Finaly, he Revealed Today that it had just reached, Nowadays, almost a ...Quadripling in Tests, with about 3.700 People Affected by that Deadly Virus !

=> By so doing, obviously, this French Team largely Slamed the Accusations made Recently by a Bogus "Study", led by Dr. Mandeep Mehra, an Indo-Pakistani Cardiologist (sic !) at "Brigham and Women's Hospital" (USA), curiously Published by "LANCET" UK Review, with a Controversial Text, (Only Based on Remote, Automatic retrieval of Registry Data, by Computers' Networks, from 671 Hospitals in 6 Continents of the World, stained by at least 11 Gros Flaws ! See: http://www.eurofora.net/newsflashes/news/bogusmoveagainsthcqdrugvvirus.html), Claiming that the pro-HCQ/AZ Scientists (as Raoult etc) would have been based Only on some ..."Anecdotal Experiences" and "Small Scale Studies" (sic !) for their Theories...

But, Already, Their "6.221" copied Case-Files reportedly Registered as Including HCQ+AZ+ Treatments, in fact, are Not Equivalent to that, but Only in 1/2 or 1/3 of cases, since they doN't concern Only Azythrimycine but Also Any Other among such "    " Category of substances, of which there are 2 or 3, etc... So that, in Fact, Only some 3.110 or even just 2.070, (Perhaps Less) Might concern Professor Raoult's HCQ+AZ Protocol !             

=> I.e., a Smaller amount of strictly "Virtual" Data Remotely and Automatically Retrieved by Computer Networks, than the "More than 3.700 Patients", in Real Physical Cases, Directly Observed and Treated by Prof. Raoult's team Nowadays...                   

--------------------------------

- Indeed, "we made a Very, very Big Study, with More than 3.600 Patients, which Allows us to have a sufficiently Clear View of what is going on", Professor Raoult Announced Today.

- "Most of them were Treated by Associating CHQ + AZ, and, among them, Mortality is O,5%, that is to say, the Lowest in the World !", he stressed.             

=> - "So, ...Here, HCQ+ Saves Many Lives !", he Concluded.

+ Advancing (for the 1st Time), even towards a Control Group approach, he Pointed out that, "By Comparing also with Other Groups" of Patients, "who Came Too Late, Walked Out, or had Counter-Indications, because of their Coditions and Age, etc., so that they were UnAble to receive that HCQ+AZ Treatment, which gives Better Results, but Only got Other, Ordinary Treatments, there was a very Significant Difference"..., and "that's Interesting".

The "HCQ-AZ" Group included more than 3.000 Patients, while more almost 700 were "treated with Other Methods", he added later-on.

=> "Early Diagnosis, ...and Early Treatment, with at least 3 Days of HCQ-AZ, Result in a Significantly Better clinical Outcome", "with a Decreased risk of Transfer to the (Intensive Care) ICU, or  Death , ..., Decreased risk of Hospitalization ≥10 days", ... and Shorter Duration of Viral shedding", (ibid).

++ And, Now, "we Know that some things which (in the Past) had been UnderEstimated, as, f.ex., the ZINC", in fact, "Play a Role in the Severity" of cases, "f.ex. People who have a Severe Pathology, have Lower Zinc Rates than Others, in addition, also, to Other Things, too, which were, meanwhile, registered".

+++ However, "we made also", in Total, "More than 10.000 Electro-Cardio-Grams (ECG), and All were Examined by a Cardiologist", so that there wasN't any Heart Incident here at all, he pointed out. - "By the way", with the due care, "HCQ may affect People Less than... even Dolipran" (a Banal Pain-Killer) "which, in fact, is the 1st Cause in the World for Poisoning !", if taken in an inappropriate way, he extrapolated. - All and all, "we had a Total of 36 Deaths" (throughout All Trials, New and Old), "from which Not even One (1) wasn't Ever related with the Heart".

>>> In General, as a matter of Principle, Prof. Raoult's Team stands for an "Early" and "Carefully Controlled Treatment, with Safe and Well-Tolerated Drugs", "in individuals with Mild Symptoms, Before signs of Severity appear", and "paying Strict Attention ...to Contra-Indications and ...Inter-Actions with concomitant Medication", as he advised, Already in the Conclusions of the Previous Trial (of 1.061 Patients), Published at the Beginning of May, (Comp. Supra).

++++ In Parallel, Additionaly, "we have made about 130.000 Diagnostic Tests by PCR in some 50.000 Patients, including Diagnosis in about 5.000 Cases which were Treated Here", Raoult Noted Today.  

=> - "So that we were among the First to say that", in principle, "Children are Not Infected, are Not Affected" by that Virus, and - "Now, we Know Why !" Something that "we will Reveal Next Week", he promised, by the way.    

  - And "we Know that there are People who are Very Sick, and  have Big Lesions (visible only) at the Scanner, While they are Not Short of Breath", but with "Minimal" "Dyspnoea" (i.e. almost "ASymptomatic", etc).  -

 - So that, "the Evolution of (such) New Diseases canNot always be Foreseen based on that of Older Diseases : Each one may have Its Own Way to Evolve".

 =>  - Thus, "we Accumulated a Considerable Amount of Data, probaly Unique in the World", "from which we Have to Make several Conclusions, Later-on, at the Right Moment - which is Not always Similar to that of the Press-Medias : Everybody lives at his Own Pace"..., he Smiled, giving RDV in a foreseable Future.

 

(../..)

 

("Drafty-News")

 

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People in Europe and the World expect from CoE to make a succes of its "Monitoring" for Human Rights and Democracy, despite difficulties, said Finland's President Tarja Halonen to "EuroFora" at a crucial moment for the mecanism built 15 years ago by the paneuropean organization which celebrates its 60th Anniversary in 2009.

Halonen, known as "Mother" of CoE's "Monitoring" mecanism, a long-time MEP and former Foreign Minister before becoming Finland's President, holds a long experience in the mattter, after also serving twice as CoE and EU Chairwoman in the past. That's why she is well placed to judge how CoE's "monitoring" should deal today with some crucial issues of importance both to CoE and to the EU.

The move came just a Month before a crucial, last visit to Turkey, scheduled for June, by the President of CoE''s "Monitoring" Committee, Ukranian MEP Serge Holovaty, to finalize his Report on Ankara, the CoE Member State with the longest Monitoring procedure. From its results depends its overall credibility.

This is a Test-case, because, in fact, it's in order to avoid Sanctions threatened against Turkey by a CoE's Assembly's April 1995 Resolution for grave Human Rights violations, Democracy gaps, the continuing Military Occupation in Cyprus, the unresolved Kurdish problem, Aegean differend with Greece, etc., that MEPs decided to create, for the 1st time on April 1996, a "Monitoring" proces, allegedly destinated to check, without excluding Countries who did not fulfill all CoE's standards.

In the Past, the obliged withdrawal of Greece's Military regime and of its "Civil" cover-up out of the CoE had helped bring back Democracy in 1974. But, on the contrary, since April 1996, the idea was to "monitor" Human Rights' respect while keeping most concerned Countries inside the CoE. After Turkey's oldest example, this was extended also to several former "Eastern" European Countries, even if CoE's Assembly has imposed to some of them (fex. Ukraine, Russia, etc., after Belarus, Serbia, etc) various "Sanctions", that Ankara always avoided. Curiously more succesful even than .. USA itself, (a CoE "Observer" since 1995), which has been at least threatened with sanctions some years ago..

EU-effects of CoE's Monitoring process became obvious between 2001-2008, since the "closure" of this procedure, when CoE felt that a Country had met most of its Human Rights, Democracy and Rule of Law obligations, (i.e. the "Copenhagen Criteria" for the EU), helped trigger Negotiations with the EU for "Accession" or other closer relations : This occured already before the 2004 and 2007 EU Enlargements to former "Eastern" European Countries, as well as for the commencement of "accession" negotiations with Croatia, and of "open-ended" negotiations with Turkey in 2005.

    But a stricking new development are Holovaty's recent findings that on core Human Rights issues as Torture and Freedom of Expression, Turkey, even "5 Years after" CoE closed its "Monitoring", back in 2004, inciting EU to start accession Negotiations in 2005, still presents grave problems.

    His findings are of crucial importance after a 2008 CoE Resolution called, "if need be", to "seriously consider the possibility of Re-Opening the Monitoring procedure for Turkey" : A move which might affect Ankara's controversial EU bid, since EU Accession Negotiations are based on the Hypothesis that the Candidate fullfils the "Copenhagen Criteria" (See above)..
-------------------------
    Holovaty expressed his will to check  "Matters still Outstanding" and  those that he "didn't have an opportunity to discuss" at an earlier visit this year, "in order to discuss the more complex issues in greater depth", at his forthcoming New Visit to Ankara, before the December 2009 EU Summit.  This is all based on the 2004 CoE Resolution which stresses that, CoE "will continue.. post-monitoring Dialogue with the Turkish authorities,...in addition to a 12-points list,..and on any Other Matter that might arise in connection with Turkey’s Obligations as a CoE member state".

    CoE's Resolution also asks  from Turkey "to secure the proper Implementation of Judgements, particularly in the Cyprus v. Turkey InterState case", of 2001, which concerns also the plight of many Hundreds of MISSING People. It adds Turkey's obligations to "execute" ECHR's Judgements in the Loizidou case,..and in particular adopt General Measures to avoid repetition or continuation of Violations found by the Court" to the detriment of Refugees.

    Nevertheless, Holovaty said to "EuroFora" that "MISSING" persons,"might be included" and cannot be excluded, but he has yet to examine the situation "to find out  which issues will be raised" to the Turkish Government.

    Therefore, "EuroFora" asked Halonen, as the Historic "Mother" of CoE's Monitoring mecanism, if she thought that, "whenever there are grave Human Rights Violations, as fex. "MISSING" persons, attested even by ECHR's judgements, they should be always checked by a Monitoring process. Or could they be forgotten ?"
    
     - "We (CoE) must be, at the same time, Fair, Realistic, but not in the mind that "now we have Forgotten", etc., replied to "EuroFora"'s question Halonen, speaking as a matter of general principle.

    - "When we think of those People that are suffering from the lack of Democracy, of Human Rights, and of the Rule of Law", "we should find a base on how to deal with the (Monitoring) system more rapidly"', she stressed.

    - "Sometimes it's very difficult to combine Transparency and Effectivenes together, particularly in this specific case", she went on to say. But, "I have not found a (CoE Member) Country who could be insensitive in this sens", Halonen answered concerning grave Human Rights violations attested by the ECHR.

    - "I have no ready-made answer. I have the expectations that you, in the CoE, will, step by step, find the different types of the monitoring systems."

    Also "because this is a part of the UN's Post-Conflict system, (fex. when it comes to Cyprus' MISSING persons), and it's a more Global system". So that, "If we make a succes in Europe, the others will follow", throughout the World.  "But they expect that we (Europe) are this opportunity, this Opportunity to make a Succes", Halonen concluded.

    In addition, she advised to extend CoE's Monitoring to all its 47 Member States, "because, as long as we hear that, all these monitoring systems are "OK for the neighbor, but not for me", "it's very difficult" to understand. Something which could make easier to Compare...

    Finnish MEP Jaako Laakso, former CoE Rapporteur on the Occupied Territories of Cyprus and one of the 5 Signatories of the Historic CoE's call to create the "MONITORING" mecanism since 1996, was more specific :  - "We (CoE Assembly) have to find a way for the issue of Cyprus' MISSING People to be better followed", he stressed, anouncing his intention to "speak to Mr. Holovaty" about that. "There might be also other ways", added Laakso.

    - The 2008 "Year had been a very Bad one for Turkey with regard to Human Rights in general, and Freedom of Expression in particular", denounced, meanwhile, Holovaty's preliminary Post-Monitoringh Draft Report by Holovaty, published by the CoE on April 2009.

    "Amnesty International believes that freedom of expression is not guaranteed given the various articles of the Criminal Code that restrict it. .. "For example, 1,300 Websites are said to have been closed down by the (Turkish) authorities in 2008" ! While "the new Turkish Criminal Code was used to bring a total of 1,072 proceedings between June 2005 and April 2008, and led to the conviction of 192 people", for expressing views. "Representatives of the Özgür Gündem newspaper, which specialises in Kurdish affairs, ..complained about Numerous Attacks on their Freedom of Expression ...as was everyone who advocated a settlement to the question by means other than the intervention of the army" "According to their figures, 19 Newspapers had been suspended 43 times between 4 August 2006 and 4 November 2008" !...

    Moreover, on 2008,  CoE's "Ministers adopted its 4rth Resolution on the execution of the judgments of the ECHR, ...and outstanding issues regarding 175 Judgements and decisions relating to Turkey delivered between 1996 and 2008...  concerning Deaths resulting from the excessive use of force by members of the Security forces, the failure to protect the right to life, the DIisappearance and/or death of individuals, Ill-Treatment and the Destruction of property". CoE's " Ministers urged the Turkish authorities ...to ensure that members of Security forces of all ranks can be prosecuted without administrative
authorisation" for "serious crimes". Holovaty reminded.

"Nonetheless", Holovaty heard anew of "Several cases of Violence committed last year (2008) by the (Turkish) security forces". Amnesty International speaks of Many Cases of ill-treatment and Torture in the prisons and by the police". "Including, fex."'the death of Engin Ceber, a young man of 29 who died on October 2008 as a result of the TORTURE allegedly inflicted on him by police officers, prison staff and members of the gendarmerie. He was part of a group of people arrested on September 2008 during a demonstration and Press Conference in Istanbul'. Proceedings against suspects are "on-going" in this case.

- " I therefore noted an Obvious Contradiction between the Government’s stated “zero tolerance” policy.... of Torture and other forms of ill-treatment, and the different testimonies given", denounced CoE's Rapporteur.  Turkish "authorities must make considerable efforts to guarantee that proper investigations are carried out into allegations of abuses by members of the security forces and that perpetrators are effectively punished" "In this respect, I have requested detailed Statistics on the number of Investigations, acquittals and convictions in cases involving allegations of abuse in order to show the positive impact of the measures taken to date", Holovaty said, repeating a permanently unsatisfied CoE's demand to Turkey since a Decade...

    - "The Political Crisis that shook the country in the spring of 2008 highlighted the Weaknesses of the (Turkish) Constitution", which comes from the Military regime of 1982, "and the Urgent Need of Reforms", stressed from the outset CoE's Rapporteur in 2009. In particular, "the ...Democratic functioning of state institutions, including the independence of the judicial system, are crucial", he observes.

    But, "the Electoral  system and the ways in which it is circumvented do not appear to give those elected complete Legitimacy, and tend to pervert the course of direct universal suffrage", denounces Holovaty, observing that, even 5 Years later, Turkey did not yet change the 10% nationwide Threshold for a party to take any seat, which is "far higher" than the "3%" maximum in Europe and already condemned as contrary to European Standards by the CoE.

    + Moreover, EU Parliament's 2009 Report on Turkey, drafted by Dutch MEP Ria Oomen-Ruijten and adopted in Strasbourg on March, expresses "Concern over the Failure of the (Turkish) Judiciary to prosecute cases of Torture and Ill-treatment, the Number of which is Growing". EU also "is concerned about continuing Hostility and Violence against Minorities" in Turkey. It also "calls on the Turkish Government to launch, as a matter of Priority, a Political Initiatve favouring a lasting Settlement of the Kurdish issue, (while "condemning violence.. and terrorist groups"). EU "regrets that No progress has been made on establishing full, systematic Civilian suprevisory functions over the (Turkish) Military".

    The final results of Holovaty's 2nd and last visit to Turkley will be known later this year, and, at any case, before EU's December 2009 Summit.

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