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Home arrow newsitems arrow Virus: Biggest Ever Trial on HCQ+AZ+Zinc Cure (3.700 Patients) Found World-Record Survival: 99,5 % !

Virus: Biggest Ever Trial on HCQ+AZ+Zinc Cure (3.700 Patients) Found World-Record Survival: 99,5 % !

Pisac ACM
25. 05. 2020.

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*Strasbourg/Angelo Marcopolo/- In the Biggest Trial Study of HCQ+AZ+ against the Virus, just Concluded this Month, among about 3.700 Patients (i.e. the Larger Ever in the World in that area, until now), the Mortality Rate was Only ...0,5%, giving a Global Record-Breaking Survival Rate of 99,5%, as Announced Today French Professor Dr. Didier Raoult, an Experienced and Famous Infectiologist/MicroBiologist Expert, CEO of Mediterranean and Infection Hospitalo-Universitarian Institute (IHU) at Marseille City, who had been already EnTrusted by Historic French President Jacques Chirac (a Gaullist) to daft a 1st Report for the Strategy of the Country's Protection from any foreseable Risk of Epidemic, already, as Early as since the Beginning of 2000ies, (just After the SARS-1 Virus of 2003+).

- Moreover, among those circa 3.700 Patients "retrospectively", treated with HCQ+AZ+ Nowadays, "we NEVER Observed Any CARDIAC Death and Toxicity", it was added by the Two main Leaders of that New Trial, (D. Raoult and Matthieu Million), where "7.800 ECG were made" on all those Patients, by measure of Precaution.

+ Already, with  "ZERO (0) Deaths" of People Infected by the COVID-19 Virus "before 70 Years of Age", and just 8 Deaths among Only those Aged "74 to to 95 Years", in a CHQ+ Trial with More than 1.060 Patients, Concluded Previously, at the End of March, and Published at a Scientific Review on May 5, 2020, the Results appeared very Positive, (See Also Infra).

Such Landmark Results also have a Key Importance for Crucial and Topical Issues of International Health Strategy at Global Level, Nowadays :

 - Indeed, the International Health Organisation (WHO), at Nearby Geneva, had Chosen, Among about 50 Various Candidates, ("Based on Evidence from Laboratory, Animal, and [Human] Clinical Studies"), the HCQ+ as 1 Among the 3 Best "Most Promising" Candidate Drugs in the World Deserving to be Tested by its Research Program for Medical Treatment against the CoronoVirus, ("Solidarity"), with 108 Millions $ Funding and about 3.500 Patients from 17 Countries.

Competitors are Only "Remdesivir" (a Failed attempt Initially v. Ebola in Congo, where it did Not work, while Other Drugs did, But Later reportedly used in Animals v. SARS-1, Needing an IntraVenous, and Expensive, Based on Genetic Manipulations expected to Block Virus' Replication, and Backed by "Gilead" Big Pharma Corporation, holding its Patent) ; and "Lopinavir"'s Combinations, (Initialy destinated to "HIV", with "Ambiguous" Results v. SARS-1 or MERS, and "Not Encouraging" First Trials v. COVID-19, it may cause "Significant" Liver Damage, But is now Tested v. MERs in Saudi Arabia).

=> So that HCQ+ appeared, until now, to be, comparatively, the Best Hope for the World Health Organisation. A Succesful Drug already against Malaria and Arthritis, Used withOut Problem Since the 2nd World War, now a "Generic", Cheap and Simple Pill, it Might Protect Cells from Virus' Attacks, Strengthening the Natural Human Immune System, But it must Avoid Side Effects, with right Precautions. About 20 Chinese Studies reportedly were Succesful against this Virus, But a Lack of Full Published "Data" was reported, with the Exception of French Professor Raoult's Tests, that Some considered Initially "InSuficient", until his Recent Work, (which, therefore, has a Crucial Importance Nowadays).

>>> Even More Important, World-wide :  It's a Fact that the WHO has, Until Now, practicaly Excluded Vaccines from its above-mentioned International Research projects, Focused Only on Treatments and Cure, (Comp. Supra), mainly Because of a "Need for Speed", in order to "Reduce the Time" usually taken by Vaccines' testing, (may be 1 or 1,5 Year+), given the Urgency in this Deadly Virus' Crisis. In Consequence, (and given also the Facts cited Supra), at least Until Now, Serious HCQ+ Trials appeared to be, in Practice, probably the Only attainable Hope to Find a way to Urgently Save currently Threatened Human Lives throughout the Planet !

--------------------------------

In this Context, Previously, Trials with HCQ+AZ+ by Prof. Raoult, concluded at the End of March, had Resulted Already High enough, with a 99,1 % Survival rate. But the New Overall Results, which just Concluded on this May, (Including Almost Four Times More Patients : See Infra),  Reached an Even Higher Survival rate : 99,5 % (i.e., by Far, the Best in the World) !

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Professor Raoult's team had Initialy Tested 36 Patients, Afterwards 80, and Later 1.061, whlle Recent Rumours evoked anew a Doubling of the Number of Patients for a New, Bigger Trial,  (i.e. about 2.000). But, Finaly, he Revealed Today that it had just reached, Nowadays, almost a ...Quadripling in Tests, with about 3.700 People Affected by that Deadly Virus !

=> By so doing, obviously, this French Team largely Slamed the Accusations made Recently by a Bogus "Study", led by Dr. Mandeep Mehra, an Indo-Pakistani Cardiologist (sic !) at "Brigham and Women's Hospital" (USA), curiously Published by "LANCET" UK Review, with a Controversial Text, (Only Based on Remote, Automatic retrieval of Registry Data, by Computers' Networks, from 671 Hospitals in 6 Continents of the World, stained by at least 11 Gros Flaws ! See: http://www.eurofora.net/newsflashes/news/bogusmoveagainsthcqdrugvvirus.html), Claiming that the pro-HCQ/AZ Scientists (as Raoult etc) would have been based Only on some ..."Anecdotal Experiences" and "Small Scale Studies" (sic !) for their Theories...

But, Already, Their "6.221" copied Case-Files reportedly Registered as Including HCQ+AZ+ Treatments, in fact, are Not Equivalent to that, but Only in 1/2 or 1/3 of cases, since they doN't concern Only Azythrimycine but Also Any Other among such "    " Category of substances, of which there are 2 or 3, etc... So that, in Fact, Only some 3.110 or even just 2.070, (Perhaps Less) Might concern Professor Raoult's HCQ+AZ Protocol !             

=> I.e., a Smaller amount of strictly "Virtual" Data Remotely and Automatically Retrieved by Computer Networks, than the "More than 3.700 Patients", in Real Physical Cases, Directly Observed and Treated by Prof. Raoult's team Nowadays...                   

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- Indeed, "we made a Very, very Big Study, with More than 3.600 Patients, which Allows us to have a sufficiently Clear View of what is going on", Professor Raoult Announced Today.

- "Most of them were Treated by Associating CHQ + AZ, and, among them, Mortality is O,5%, that is to say, the Lowest in the World !", he stressed.             

=> - "So, ...Here, HCQ+ Saves Many Lives !", he Concluded.

+ Advancing (for the 1st Time), even towards a Control Group approach, he Pointed out that, "By Comparing also with Other Groups" of Patients, "who Came Too Late, Walked Out, or had Counter-Indications, because of their Coditions and Age, etc., so that they were UnAble to receive that HCQ+AZ Treatment, which gives Better Results, but Only got Other, Ordinary Treatments, there was a very Significant Difference"..., and "that's Interesting".

The "HCQ-AZ" Group included more than 3.000 Patients, while more almost 700 were "treated with Other Methods", he added later-on.

=> "Early Diagnosis, ...and Early Treatment, with at least 3 Days of HCQ-AZ, Result in a Significantly Better clinical Outcome", "with a Decreased risk of Transfer to the (Intensive Care) ICU, or  Death , ..., Decreased risk of Hospitalization ≥10 days", ... and Shorter Duration of Viral shedding", (ibid).

++ And, Now, "we Know that some things which (in the Past) had been UnderEstimated, as, f.ex., the ZINC", in fact, "Play a Role in the Severity" of cases, "f.ex. People who have a Severe Pathology, have Lower Zinc Rates than Others, in addition, also, to Other Things, too, which were, meanwhile, registered".

+++ However, "we made also", in Total, "More than 10.000 Electro-Cardio-Grams (ECG), and All were Examined by a Cardiologist", so that there wasN't any Heart Incident here at all, he pointed out. - "By the way", with the due care, "HCQ may affect People Less than... even Dolipran" (a Banal Pain-Killer) "which, in fact, is the 1st Cause in the World for Poisoning !", if taken in an inappropriate way, he extrapolated. - All and all, "we had a Total of 36 Deaths" (throughout All Trials, New and Old), "from which Not even One (1) wasn't Ever related with the Heart".

>>> In General, as a matter of Principle, Prof. Raoult's Team stands for an "Early" and "Carefully Controlled Treatment, with Safe and Well-Tolerated Drugs", "in individuals with Mild Symptoms, Before signs of Severity appear", and "paying Strict Attention ...to Contra-Indications and ...Inter-Actions with concomitant Medication", as he advised, Already in the Conclusions of the Previous Trial (of 1.061 Patients), Published at the Beginning of May, (Comp. Supra).

++++ In Parallel, Additionaly, "we have made about 130.000 Diagnostic Tests by PCR in some 50.000 Patients, including Diagnosis in about 5.000 Cases which were Treated Here", Raoult Noted Today.  

=> - "So that we were among the First to say that", in principle, "Children are Not Infected, are Not Affected" by that Virus, and - "Now, we Know Why !" Something that "we will Reveal Next Week", he promised, by the way.    

  - And "we Know that there are People who are Very Sick, and  have Big Lesions (visible only) at the Scanner, While they are Not Short of Breath", but with "Minimal" "Dyspnoea" (i.e. almost "ASymptomatic", etc).  -

 - So that, "the Evolution of (such) New Diseases canNot always be Foreseen based on that of Older Diseases : Each one may have Its Own Way to Evolve".

 =>  - Thus, "we Accumulated a Considerable Amount of Data, probaly Unique in the World", "from which we Have to Make several Conclusions, Later-on, at the Right Moment - which is Not always Similar to that of the Press-Medias : Everybody lives at his Own Pace"..., he Smiled, giving RDV in a foreseable Future.

 

(../..)

 

("Drafty-News")

 

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Speaking exclusively to "EuroFora", the New EU Parliament's President, former Polish Prime Minister, ChristianDemocrat/EPP MEP Jerzy Busek, welcomed proposals by EuroFora about innovative ways for EU Citizens to attend EU debates before important final decisions which affect people's lives.

- "We (EU Parliament) must be transparent", Buzek stressed from the outset.  "We must have clear answers also for delicate questions. If we don't touch a problem, you must know why, and when shall we decide in the nearest future".. "Because "we (EU) must think about Europeans, first of all : They don't understand well what is going on in the EU. So, it's our duty to inform them, to make discussions here more interesting".

"EuroFora" congratulated President Buzek for the anouncement he made, from the 1st day of his election in Strasbourg (on Tuesday, 14 July 2009), on his intention to make  transparent debates, exchanges of views, etc. before the final adoption of decisions in EU Parliament's Plenary, when issues are evolving inside Committees, (See earlier publication).

And we reminded, in this regard, that "EuroFora" has been advocating a project for EU Citizens' active involvement in pluralist EU debates before important EU decisions, since more than a Decade : 1997-2007+

- "Thank you. We (EU Parliament), indeed, have exciting debates", Buzek replied. But, in practice, "without a possibility for our Citizens to see them, not even by the Press, the Radio or TV, etc., because it is in Committees", he regreted.

- "But, they (i.e. Media, Citizens, etc) might interact with you, with MEPs, etc, May be we can imagine something", "EuroFora" proposed.

- "Yes, (but) it needs, a quite new idea", Buzed observed.

- "Why not through some innovations ?", "EuroFora" suggested.

- "Innovation ? That's it. Fantastic  New Information Technologies !", Buzek realized.

- "Precisely, "EuroFora" has such a project, since more than a Decade (1997-2009), to use new technologies for public debates before major EU decisions are taken", we reminded.

- "If you have such proposals, please come to us, come to us. We must" do something, agreed the new EU Parliamen's President.

buzek_chairing_400 

    This fits with Buzek's main stance, expressed at EU Parliament's plenary earlier this week in Strasbourg, that the European Union must succeed to overcome a "Crisis of Trust" vis a vis EU Citizens. (See previous EuroFora publication).

    For that purpose, obviously information and debates are valuable, but purely instrumental, procedural means which can help focus on, and highlight a substantial content, attractive to EU Citizens, which needs to be determined by other, political, and not mediatic factors.  

    Buzek spoke about the urgent need to overcome the Global Economic Crisis,  the struggle for Human and Civic Rights, Democracy, etc., the Eastern Partnership, links with Russia, strategic partnership with USA and emerging countries, etc.

    But he also used (while speaking both to "EuroFora" and other Media) the expression : "The Europeans", for EU Citizens. This points right towards what several important EU leaders (including French President Sarkozy, German Chancellor Merkel, etc) have started to highlight particularly during the recent years : That there is a vital need, and an historic opportunity, for the development of a European Conscience, to stimulate e renaissance of a European Identity able to attract Popular support, for the EU to become a strong player in a Multopolar World : In other words, the revitalisation of a project for a "Political Europe".

    By a coincidence, this was indirectly but surely reminded, earlier in Strasbourg, by another ... Busek (this time with a "s") : 

busekcoe_400

    Speaking to more than 650 participants from CoE's member countries, at the conclusion of the 2009 Summer University of its Political Schools, Erhard Busek, (with an "s"), former vice-Chancellor of Austria and EU Coordinator for South-Eastern Europe, pointed at the current need to revitalize Europe's "Identity", forged by Greek philosophy and Roman Law, Christian values and Enlightment's ideas, etc. through the ages.     

- "We have almost the same name with Jerzy Buzek (EU Parliament's new President, who is a former Polish Prime Minister), because both our Families come ...from  the same village, located at the Heart of Europe, which was often shared between Poland, Germany and the Czech Republic. But my family emmigrated a long time ago to Austria, while Jerzy Buzek's family remained in Poland", explained f. vice-Chancellor Erhard Busek to "EuroFora".   

 An astonishingly concrete and simple example of European Integration from the grassroots : Starting by EU Citizens, i.e. those "Europeans", that EU Parliament's new President, Jerzy Buzek (this time with a "z"), wants to bring alongside MEP's decision-making proces, (according to "EuroFora"'s main idea : Comp. supra)...

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