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Pagina principale arrow newsitems arrow Virus: Biggest Ever Trial on HCQ+AZ+Zinc Cure (3.700 Patients) Found World-Record Survival: 99,5 % !

Virus: Biggest Ever Trial on HCQ+AZ+Zinc Cure (3.700 Patients) Found World-Record Survival: 99,5 % !

Scritto da ACM
Monday, 25 May 2020

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*Strasbourg/Angelo Marcopolo/- In the Biggest Trial Study of HCQ+AZ+ against the Virus, just Concluded this Month, among about 3.700 Patients (i.e. the Larger Ever in the World in that area, until now), the Mortality Rate was Only ...0,5%, giving a Global Record-Breaking Survival Rate of 99,5%, as Announced Today French Professor Dr. Didier Raoult, an Experienced and Famous Infectiologist/MicroBiologist Expert, CEO of Mediterranean and Infection Hospitalo-Universitarian Institute (IHU) at Marseille City, who had been already EnTrusted by Historic French President Jacques Chirac (a Gaullist) to daft a 1st Report for the Strategy of the Country's Protection from any foreseable Risk of Epidemic, already, as Early as since the Beginning of 2000ies, (just After the SARS-1 Virus of 2003+).

- Moreover, among those circa 3.700 Patients "retrospectively", treated with HCQ+AZ+ Nowadays, "we NEVER Observed Any CARDIAC Death and Toxicity", it was added by the Two main Leaders of that New Trial, (D. Raoult and Matthieu Million), where "7.800 ECG were made" on all those Patients, by measure of Precaution.

+ Already, with  "ZERO (0) Deaths" of People Infected by the COVID-19 Virus "before 70 Years of Age", and just 8 Deaths among Only those Aged "74 to to 95 Years", in a CHQ+ Trial with More than 1.060 Patients, Concluded Previously, at the End of March, and Published at a Scientific Review on May 5, 2020, the Results appeared very Positive, (See Also Infra).

Such Landmark Results also have a Key Importance for Crucial and Topical Issues of International Health Strategy at Global Level, Nowadays :

 - Indeed, the International Health Organisation (WHO), at Nearby Geneva, had Chosen, Among about 50 Various Candidates, ("Based on Evidence from Laboratory, Animal, and [Human] Clinical Studies"), the HCQ+ as 1 Among the 3 Best "Most Promising" Candidate Drugs in the World Deserving to be Tested by its Research Program for Medical Treatment against the CoronoVirus, ("Solidarity"), with 108 Millions $ Funding and about 3.500 Patients from 17 Countries.

Competitors are Only "Remdesivir" (a Failed attempt Initially v. Ebola in Congo, where it did Not work, while Other Drugs did, But Later reportedly used in Animals v. SARS-1, Needing an IntraVenous, and Expensive, Based on Genetic Manipulations expected to Block Virus' Replication, and Backed by "Gilead" Big Pharma Corporation, holding its Patent) ; and "Lopinavir"'s Combinations, (Initialy destinated to "HIV", with "Ambiguous" Results v. SARS-1 or MERS, and "Not Encouraging" First Trials v. COVID-19, it may cause "Significant" Liver Damage, But is now Tested v. MERs in Saudi Arabia).

=> So that HCQ+ appeared, until now, to be, comparatively, the Best Hope for the World Health Organisation. A Succesful Drug already against Malaria and Arthritis, Used withOut Problem Since the 2nd World War, now a "Generic", Cheap and Simple Pill, it Might Protect Cells from Virus' Attacks, Strengthening the Natural Human Immune System, But it must Avoid Side Effects, with right Precautions. About 20 Chinese Studies reportedly were Succesful against this Virus, But a Lack of Full Published "Data" was reported, with the Exception of French Professor Raoult's Tests, that Some considered Initially "InSuficient", until his Recent Work, (which, therefore, has a Crucial Importance Nowadays).

>>> Even More Important, World-wide :  It's a Fact that the WHO has, Until Now, practicaly Excluded Vaccines from its above-mentioned International Research projects, Focused Only on Treatments and Cure, (Comp. Supra), mainly Because of a "Need for Speed", in order to "Reduce the Time" usually taken by Vaccines' testing, (may be 1 or 1,5 Year+), given the Urgency in this Deadly Virus' Crisis. In Consequence, (and given also the Facts cited Supra), at least Until Now, Serious HCQ+ Trials appeared to be, in Practice, probably the Only attainable Hope to Find a way to Urgently Save currently Threatened Human Lives throughout the Planet !

--------------------------------

In this Context, Previously, Trials with HCQ+AZ+ by Prof. Raoult, concluded at the End of March, had Resulted Already High enough, with a 99,1 % Survival rate. But the New Overall Results, which just Concluded on this May, (Including Almost Four Times More Patients : See Infra),  Reached an Even Higher Survival rate : 99,5 % (i.e., by Far, the Best in the World) !

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Professor Raoult's team had Initialy Tested 36 Patients, Afterwards 80, and Later 1.061, whlle Recent Rumours evoked anew a Doubling of the Number of Patients for a New, Bigger Trial,  (i.e. about 2.000). But, Finaly, he Revealed Today that it had just reached, Nowadays, almost a ...Quadripling in Tests, with about 3.700 People Affected by that Deadly Virus !

=> By so doing, obviously, this French Team largely Slamed the Accusations made Recently by a Bogus "Study", led by Dr. Mandeep Mehra, an Indo-Pakistani Cardiologist (sic !) at "Brigham and Women's Hospital" (USA), curiously Published by "LANCET" UK Review, with a Controversial Text, (Only Based on Remote, Automatic retrieval of Registry Data, by Computers' Networks, from 671 Hospitals in 6 Continents of the World, stained by at least 11 Gros Flaws ! See: http://www.eurofora.net/newsflashes/news/bogusmoveagainsthcqdrugvvirus.html), Claiming that the pro-HCQ/AZ Scientists (as Raoult etc) would have been based Only on some ..."Anecdotal Experiences" and "Small Scale Studies" (sic !) for their Theories...

But, Already, Their "6.221" copied Case-Files reportedly Registered as Including HCQ+AZ+ Treatments, in fact, are Not Equivalent to that, but Only in 1/2 or 1/3 of cases, since they doN't concern Only Azythrimycine but Also Any Other among such "    " Category of substances, of which there are 2 or 3, etc... So that, in Fact, Only some 3.110 or even just 2.070, (Perhaps Less) Might concern Professor Raoult's HCQ+AZ Protocol !             

=> I.e., a Smaller amount of strictly "Virtual" Data Remotely and Automatically Retrieved by Computer Networks, than the "More than 3.700 Patients", in Real Physical Cases, Directly Observed and Treated by Prof. Raoult's team Nowadays...                   

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- Indeed, "we made a Very, very Big Study, with More than 3.600 Patients, which Allows us to have a sufficiently Clear View of what is going on", Professor Raoult Announced Today.

- "Most of them were Treated by Associating CHQ + AZ, and, among them, Mortality is O,5%, that is to say, the Lowest in the World !", he stressed.             

=> - "So, ...Here, HCQ+ Saves Many Lives !", he Concluded.

+ Advancing (for the 1st Time), even towards a Control Group approach, he Pointed out that, "By Comparing also with Other Groups" of Patients, "who Came Too Late, Walked Out, or had Counter-Indications, because of their Coditions and Age, etc., so that they were UnAble to receive that HCQ+AZ Treatment, which gives Better Results, but Only got Other, Ordinary Treatments, there was a very Significant Difference"..., and "that's Interesting".

The "HCQ-AZ" Group included more than 3.000 Patients, while more almost 700 were "treated with Other Methods", he added later-on.

=> "Early Diagnosis, ...and Early Treatment, with at least 3 Days of HCQ-AZ, Result in a Significantly Better clinical Outcome", "with a Decreased risk of Transfer to the (Intensive Care) ICU, or  Death , ..., Decreased risk of Hospitalization ≥10 days", ... and Shorter Duration of Viral shedding", (ibid).

++ And, Now, "we Know that some things which (in the Past) had been UnderEstimated, as, f.ex., the ZINC", in fact, "Play a Role in the Severity" of cases, "f.ex. People who have a Severe Pathology, have Lower Zinc Rates than Others, in addition, also, to Other Things, too, which were, meanwhile, registered".

+++ However, "we made also", in Total, "More than 10.000 Electro-Cardio-Grams (ECG), and All were Examined by a Cardiologist", so that there wasN't any Heart Incident here at all, he pointed out. - "By the way", with the due care, "HCQ may affect People Less than... even Dolipran" (a Banal Pain-Killer) "which, in fact, is the 1st Cause in the World for Poisoning !", if taken in an inappropriate way, he extrapolated. - All and all, "we had a Total of 36 Deaths" (throughout All Trials, New and Old), "from which Not even One (1) wasn't Ever related with the Heart".

>>> In General, as a matter of Principle, Prof. Raoult's Team stands for an "Early" and "Carefully Controlled Treatment, with Safe and Well-Tolerated Drugs", "in individuals with Mild Symptoms, Before signs of Severity appear", and "paying Strict Attention ...to Contra-Indications and ...Inter-Actions with concomitant Medication", as he advised, Already in the Conclusions of the Previous Trial (of 1.061 Patients), Published at the Beginning of May, (Comp. Supra).

++++ In Parallel, Additionaly, "we have made about 130.000 Diagnostic Tests by PCR in some 50.000 Patients, including Diagnosis in about 5.000 Cases which were Treated Here", Raoult Noted Today.  

=> - "So that we were among the First to say that", in principle, "Children are Not Infected, are Not Affected" by that Virus, and - "Now, we Know Why !" Something that "we will Reveal Next Week", he promised, by the way.    

  - And "we Know that there are People who are Very Sick, and  have Big Lesions (visible only) at the Scanner, While they are Not Short of Breath", but with "Minimal" "Dyspnoea" (i.e. almost "ASymptomatic", etc).  -

 - So that, "the Evolution of (such) New Diseases canNot always be Foreseen based on that of Older Diseases : Each one may have Its Own Way to Evolve".

 =>  - Thus, "we Accumulated a Considerable Amount of Data, probaly Unique in the World", "from which we Have to Make several Conclusions, Later-on, at the Right Moment - which is Not always Similar to that of the Press-Medias : Everybody lives at his Own Pace"..., he Smiled, giving RDV in a foreseable Future.

 

(../..)

 

("Drafty-News")

 

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Sarkozy and Merkel : June 2009 solution to May 2005 "NO" ?

 - Will French President Nicolas Sarkozy and German Chancellor Angie Merkel live up from June 2009 to their obvious Historic European mission to revitalize, and re-launch the "European Dream", after the series of 3 "NO" since May 2005 in France, the Netherlands and Ireland, by renewing, and changing the EU with fresh stimulus, big horizons, and values attractive for EU Citizens ?

Whatever views anyone might have, it's a Fact that, recently, EU's political spectrum didn't produce other more charismatic and popular EU leaders than Merkel and Sarkozy, starting from September 2005 and May 2007, respectively.

This trend was confirmed, in one way or another, both during the German EU presidency in 2007 (shared by Merkel with the SPD), and mainly during the French EU Presidency in 2008, (with Sarkozy "free" to move).


The positive 2009 EU Polls are a natural consequence :

- Both with 72% Sarkozy and Merkel are considered by EU Citizens to be "the most Influential" leaders in Europe, by far.

- They are the only EU political leaders to attract a Majority of "Positive" views by EU Citizens, (Merkel over 60%, Sarkozy over 50%, particularly in the continent).

- 60% of EU Citizens find the 2008 French EU Presidency "Good", (and the satisfaction grows up to 67,5% in continental Europe).

The Poll was made by "OpinionWay" in big EU countries as Germany, Italy, Spain and the UK, (with the only exception of France), from 26 to 28 May 2009.

sarkozy_merkel_polls_400

But the most important is that both Franco-German leaders seem willing to, at last, really start serious business on EU's indispensable renovation and Renaissance from 2009 : Year of crucial EU and German Elections.

Therefore, this time, the joint European move by Sarkozy and Merkel, which just published a common Franco-German Manifesto, aims to stimulate aspirations and action not only in their respective countries, but also in many other EU "partners", as they say.

Both on EU economy, social values and scientifico-technologic research, as well as on Turkey's controversial EU bid, obviously incompatible with a popular Political Europe, whose Citizens can find a collective Identity and popular Values, they have already started to magnetize various growing voices accross the European landscape :

"Today, more than ever, it' time for action", they stress from the outset.

Facing "an unprecedented Global financial and economic Crisis", "Europeans must get resolutely involved if they want for the World which is being built to meet their Values of Liberty, Solidarity and Justice".

"That's what we want" and "propose to our Partners" :

* "A strong Europe, able to protect us" :

- "We refuse a Bureaucratic EU, which mecanically applies burdensome rules and is afraid of change. We want a European Union which listens what Citizens have to say, which innovates, stimulates".

- "We want a strong and united EU in the World, while also respecting its Member States' Diversity", which "brings Courageous Replies to the Questions of our Times, ensuring our Prosperity :  

This implies to "favor Research and Innovation", "Economic Coordination", to "develop real Policies on Immigrationn, Energy, Defence, and modernise  common policies, particularly Agriculture".

*  "EU must bring immediate replies to the Global Crisis".

- "Lawless liberalism failed". "The Model we want is that of a Responsible Market Economy, which favors Enterpreneurs and Workers, above Speculators ;  Long-term Investment, over immediate profiits".

- "We appeal upon the EU to take, from June, the first decisions to ensure a real European Regulation of Financial Markets, based on coordination and cooperation". "On speculative funds, on fiscal heavens, CEO's and financial operators' earnings, EU must give the example".

- "We call to change the rules of accounts, which are important for our Economy's revival : The competent normative authorities must take action". "The issue of a sufficient Credit offer is of central importance for our Economy". "We don't accept that, during this Financial Crisis, the European Banks' capacity to lend money might be unjustly reduced by Capital's requirements and accountant's rules

* "During the German and French Presidencies, EU has resoçlutely prepared itself for the fight against Global Warming... EU is the 1st and only area in the World to have adopted a package of ambitious and legally binding rules to comply with International Aims"

- "We have now to convince our Friends and Partners, to get involved, in order to atteint, next December at Copenhagen, a Global Agreement worthy of whay is at stake. Our closer ally, the US, but also other big industrial countries, must commit themselves with the same force as the Europeans".

"Green Growth is a Chance ... and an opportunity to create jobs turned towards the Future. Europe must be a leader".

- But, at the same time, we must ensure that our companies remain competitive in the World. The ambitious European involvements on Climat must not lead into a position where EU industry might become a Victim of Unfair Competition. Climat protection and Competitvity must go together. If our International partners refuse to associate themselves to our efforts, we are determined to take measures to protect European Industry"

* "Europe must be more ambitious for its Industry" : "It must favor the emergence of strong European enterprises at a Global level".

- "As long as an International mechanism" to "monitor Public Aids at WTO level, and hinder 3rd Countries to give abusive subsidies to their enterprises, provoking unfair competition", is "not yet set up, we must consider Transitory European Solutions".

* "The current Public Debt is too heavy... We must head anew towards sound public finance, as soon as we'd have passed the crucial stage in this crisis".
-------------------------------------------------

* Last, but not least :  "Europe must play a top-level role in the World"

- "For that purpose,  it needs efficient Institutions. That's why we need Lisbon Treaty". "The 27 Member States decided, last December (2008) that the Treaty should enter into force before the end of this year (2009)". To obtain that, June EU Council must agree "on the Guarantees for Ireland".

- But, "to be able to act, EU needs Borders. An Enlargment without Limits is not possible", Sarkozy and Merkel stressed in an obvious reference to Turkey, etc.

- "In order to be strong, Europe must assume its Values and its Identity". "Human Rights .. are at the basis of our commitment for a Peaceful Development accross the World".

- "For that purpose, we shall strengthen our common Defence and Security policy".
----------------------

* "We are ready to contribute to activate the EU towards the realisation of these aims, with our EU Partners".

"In order to succeed", Europe  "needs the active involvment of all, starting by Citizens themselves. That's why the June 7 rendez-vous is important", and "we are calling all Europeans to vote".

"We are convinced that, if Europe wants, Europe can", they conclude.
-----------------------

Precisely : - What can better forge "Europe's Will" than a "European Consciousness" emerging from political, democratic struggles to face Global Challenges, and open big New Horizons, including by crystal-clear Public Debates, with active EU Citizens' involvement, before the most important EU Decisions affecting People's lives ?

Precisely what "EuroFora"s project warns since 1997-2007, and unprecedented Majority Abstentions, since 1999-2004, added to 3 "NO" to EU Referenda in 2005 and 2007, proved meanwhile..

Let's hope that the Time wasted by some scandalous anti-European and anti-Democratic obstacles of the Past, will stimulate faster, simplified but substantial and persistent, efficient action.-

Polls

2009 EU Elections were won by Parties against Technocracy and Turkey's controversial EU bid, while the 1999-2004 Majority Abstention trend decelerated. What should be done in 2009-2014 ?

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